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Submitted on January 8, 2002
Revised on April 2, 2002
Accepted on April 2, 2002

Complementary profiling of gene expression at the transcriptome and proteome levels in S. cerevisiae

Timothy J. Griffin, Steven P. Gygi, Trey Ideker, Beate Rist, Jimmy Eng, Leroy Hood, and Ruedi Aebersold

Institute for Systems Biology, Seattle, WA 98103

Corresponding Author: raebersold{at}systemsbiology.org

Using an integrated genomic and proteomic approach, we have investigated the effects of carbon source perturbation on steady-state gene expression in the yeast S. Cerevisiae growing on either galactose or ethanol. For many genes, significant differences between the abundance ratio of the messenger RNA transcript and the corresponding protein product were observed. Insights into the perturbative effects on genes involved in respiration, energy generation and protein synthesis were obtained that would not have been apparent from measurements made at either the messenger RNA or protein level alone, illustrating the power of integrating different types of data obtained from the same sample for the comprehensive characterization of biological systems and processes.


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