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FIG. 1. Association network among the genes harboring the DAVs associated with T2DM as obtained using Pathway Assist. Star denotes genes harboring DAVs of T2DM. NEUROD1, neurogenic differentiation-1; TCF4, hepatic nuclear factor 4 ${alpha}$ ; TCF1, hepatic nuclear factor 1 ${alpha}$ ; TNF, tumor necrosis factor; HGF, hepatocyte growth factor; EGF, epidermal growth factor; APOC3, apolipoprotein C3; INS, insulin; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; TGFB, transforming growth factor ß; PPARG, PPAR ${gamma}$ ; LDL, low density lipoprotein; HDL, high density lipoprotein; PKC, protein kinase C; IFNG, interferon ${gamma}$ ; IL1B, interleukin-1ß; IL4, interleukin-4; FABP2, fatty acid-binding protein 2; GCK, glucokinase; NOS3, nitric-oxide synthase isoform 3; LPL, lipoprotein lipase; SOD2, superoxide dismutase 2; LEP, leptin; LEPR, leptin receptor; NPY, neuropeptide Y; Prot, protein; Func, function; SmallMol, small molecule; MolTransport, molecular transport; PRKCE, protein kinase C epsilon; ADRB3, ß 3 adrenergic receptor; AGT, angiotensin I; WFS1, wolframin; AKT1, RAC-serine/threonine protein kinase; UTS2, urotensin II; PTEN, phosphotidyl inositol-3,4,5-triphosphate 3-phosphatase; LMNA, lamin A/C; AGER, advanced glycosylation end product-specific receptor; NR3C1, glucocorticoid receptor; TFRC, transferrin receptor; HFE, hereditary hemachromatosis protein; SELL, selectin L; ADRB2, ß 2 adrenergic receptor.

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